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TRINTELLIX (VORTIOXETINE) INDICATIONS?

Trintellix is an oral antidepressant medication with the generic name of vortioxetine. It is an oral prescription indicated to treat individuals with major depressive disorder (MDD).

Depression is one of the most damaging mental problems that will not simply go away without proper treatment. However, Trintellix’s mechanism of action may help improve your thought processes, lessens anxiety, and encourages you to be more active and enjoy daily activities.

When Trintellix is taken correctly and absorbed into the bloodstream, it prevents the reuptake of serotonin (5-HT). Serotonin is a neurotransmitter produced in the body, responsible for regulating brain functions. Restoring and regulating this chemical messenger allows serotonin to circulate and stay in the brain for prolonged periods. Therefore, it helps and allows you to think more clearly, and improves your mood and behavior.

TRINTELLIX (VORTIOXETINE) USES AND DOSAGE

Trintellix can help treat adult individuals with a mental problem like major depressive disorder (MDD) to reduce symptoms associated with depression so that you can participate actively in day-to-day activities.

Individuals need varying dosages of Trintellix depending on the need of the patient. Usually, the frequency and dosage are based on the severity of the client’s mental health condition, other coexisting medical problems, age, and tolerance to the medicine.

When using this oral medication, make sure to read all prescription information and follow all the directions thoroughly. If you are uncertain about how to use Trintellix, talk to your doctor or pharmacist for clarification.

The following are the Trintellix recommended dosages:

  • The typical starting dose for patients with MDD is 10 mg once daily. This intake can be raised to 20 mg as tolerated, depending on how your body responds to the medication. The dosage can be decreased to 5 mg per day for patients who cannot tolerate higher doses
  • The maximum suggested intake for CYP2D6 poor metabolizers or in patients taking CYP2D6 inhibitors is 10 mg once a day.

The following are the directions for administering Trintellix:

  • Administer this regimen by mouth once a day or as prescribed by your doctor
  • Take Trintellix without regard to food.

SIDE EFFECTS OF TRINTELLIX (VORTIOXETINE)

Vortioxetine may have unwanted side effects like similar medicines that may resolve when your body has adjusted to it.

The following are the common side effects of Trintellix that can occur after taking Trintellix:

  • Nausea
  • Vomiting
  • Constipation

SERIOUS SIDE EFFECTS

  • Increased suicidal thoughts
  • Attempts to harm oneself
  • Trouble sleeping
  • Hyperactivity
  • Unusual changes in behavior or mood
  • New or worsening depression, anxiety, or irritability
  • Panic attacks
  • Serotonin syndrome:
    • Agitation
    • Hallucination
    • Coma
    • Fast heartbeat
    • Uncontrolled muscle movement
    • Low or high blood pressure
    • Sweating
    • Fever
    • Diarrhea
    • Muscle stiffness
    • Nausea
    • Vomiting
  • Abnormal bleeding or bruising
  • Visual problems
  • Low sodium levels
  • Hypomania (manic episodes)

ALLERGIC REACTIONS

  • Skin rash
  • Hives
  • Skin blisters or peeling
  • Swelling (face/tongue/throat)
  • Trouble breathing or swallowing

Note that this list does not include all the drug information and health implications related to Trintellix. If you experience other side effects not listed above, consult your healthcare provider for additional information.

TRINTELLIX (VORTIOXETINE) CAUTIONS

Before using Trintellix, make sure to fully disclose your health history to your doctor, especially if you have the following medical conditions:

  • Liver problems
  • History or actively seizures or convulsions
  • Mania or bipolar disorder
  • Low serum sodium levels
  • History or actively bleeding
  • Drinking alcohol
  • Pregnant or trying to become pregnant
  • Breastfeeding

Do not take Trintellix if you are allergic to vortioxetine or any of its components. Also, do not use this antidepressant while taking monoamine oxidase inhibitor (MAOI) medication or within 14 days of stopping an MAOI, as this can cause serotonin syndrome, which can be potentially fatal.

Make sure to avoid drinking alcohol while taking Trintellix to reduce the risk of unwanted side effects.

Be careful when using Trintellix because of the increased risk of suicide for young individuals. Phone your doctor immediately if you notice sudden changes in mood, thoughts, or behavior.

Make sure to avoid doing tasks such as driving, operating heavy machinery, or doing other dangerous activities, as Trintellix may increase your risk of injuries or mishaps.

Inform your doctor about all your medicine that can interact withvortioxetine:

  • Medications for migraine headaches (e.g., triptans)
  • Medicines for mood, anxiety, and psychotic disorders (e.g., tricyclics, lithium)
  • MAOIs (e.g., selegiline, linezolid)
  • Tramadol
  • St John’s wort
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Aspirin
  • Warfarin
  • Diuretics
  • Rifampicin
  • Carbamazepine
  • Phenytoin
  • Quinidine

Keep these antidepressant tablets out of reach of the children and store them safely to preserve their effectiveness.

TRINTELLIX (VORTIOXETINE) FORM AND STRENGTH

This antidepressant medication is available in tablet formulation with the following strengths:

  • Trintellix
    • 5 mg film-coated tablet
    • 10 mg film-coated tablet
    • 15 mg film-coated tablet
    • 20 mg film-coated tablet

FAQ

What is the difference between Trintellix and Zoloft?

Both antidepressant medications are used to treat patients with major depressive disorder (MDD). The former contains vortioxetine, while the latter has sertraline as an active ingredient. The starting daily dose for Trintellix is 10 mg, while the suggested intake for Zoloft is 50 mg once a day. 

Is Trintellix a happy pill?

Trintellix is an antidepressant medication used to treat symptoms associated with MDD. This therapy helps improve your thought processes, lessens anxiety, and encourages you to be more active and enjoy daily activities.

What are the common side effects of Trintellix?

Like similar medications, the side effects of Trintellix include nausea, constipation, and vomiting. If it persists or if you experience other unwanted side effects from Trintellix, contact your doctor immediately.

How does Trintellix work?

Trintellix helps prevent the reuptake of serotonin (5-HT), a neurotransmitter responsible for several brain functions. This medicine can help restore the levels of serotonin in the brain, so it can circulate and stay for prolonged periods, reducing symptoms associated with MDD. As a result, it helps and allows you to think more clearly, and improves your mood and behavior, so that you may participate actively in day-to-day activities.

Additional information

Brand Name:

Trintellix

Scientific Name:

Vortioxetine

Other Names:

Brintellix, Fonksera, Trintellix, Voxitin

Strength(s):

5mg, 10mg, 15mg, 20mg

Quantities Available:

28, 56, 84, 100

Formulation:

Film Coated Tablet

MedicationsCanada.com receives the above information for Trintellix (Vortioxetine) from third parties. We provide this information for general informational purposes only, and it is not intended to replace the advice of a physician. Any medical concerns should always be discussed with your doctor or a qualified health care professional.