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What is Pradaxa? 

Pradaxa (dabigatran etexilate mesylate) is an oral direct thrombin inhibitor indicated to reduce the risk of stroke and systemic blood clots among patients with non-valvular atrial fibrillation. This drug works by impeding thrombus formation through the inhibition of thrombin from converting fibrinogen into fibrin during the coagulation cascade. As a result, it could treat and prevent deep vein thrombosis or pulmonary embolism. 

The medication is available in 75 mg and 150 mg capsules. 

Directions in using Pradaxa 

First, read the medication leaflet that comes with this medication. Go through each section. You must understand the information in the printed guide. If you have any questions, you may direct your queries to your doctor or healthcare provider. 

Take this medication orally, with or without a meal. Drink a full glass of water afterward. In addition, swallow this drug and do not split or cut this capsule. If you do so, this will release the drug into the system all at once, thus, increasing the side effects. 

Pradaxa dosing 

Make sure to take this medication regularly. Do not alter your Pradaxa dosing or stop taking it without the advice of your physician. Your dosing would depend on factors like a medical condition, response to treatment, kidney function, and other drugs you are taking.  

If you are taking this medication to prevent blood clots after hip or knee replacement surgery, take it exactly as prescribed by your doctor. Do not take antacids 24 hours after surgery because it may lessen the efficacy of this medication. If you experience stomach upset, take Pradaxa with food. 

What are the side effects of Pradaxa? 

Common side effects of Pradaxa: 

  • Nausea
  • Heartburn
  • Indigestion
  • Stomach pain
  • Diarrhea
  • Easy bruising 

Severe side effects of Pradaxa: 

  • Severe heartburn
  • Persistent vomiting
  • Unusual swelling
  • Prolonged bleeding
  • Blood in the urine
  • Black or bloody stool
  • Severe headache
  • Fainting 

Most people who are taking this drug experience mild adverse effects that resolve on their own. However, if you experience serious adverse reactions, discontinue taking this medication, consult your physician, or immediately alert your healthcare provider. 

Warnings and Precautions 

Look out for possible allergic reactions when you take this drug. Do not take his medication if you have a known allergy to dabigatran or any inactive ingredients this capsule may contain. Seek emergency care when you observe itchiness, red patches on the skin, severe headache, swelling of the face, and breathing difficulty. 

It is important to inform your physician about your medical condition or if you have a history of heart disease, kidney disease, liver disease, stroke, a blood disorder, a bleeding problem, or frequent falls/injuries. Some conditions or medications you are taking, including supplements, may affect how you respond to the treatment. 

Pradaxa reversal 

As Pradaxa may cause heavy bleeding, be cautious when using sharp objects like knives or nail cutters. Also, use an electric razor when shaving and a toothbrush with soft bristles when brushing your teeth. When unusual bleeding occurs, contact your physician. A Pradaxa reversal agent called Praxbind might be necessary. 

This medication may also cause stomach bleeding. To prevent this, limit alcohol and other similar beverages or food that could trigger bleeding in the stomach. 

If possible, do not get injections in the muscle. If it is necessary, ask to be injected into the deltoid muscle (arm). This area is easy to check and can easily be applied with pressure bandages. 

There are no definitive studies for pregnant and breastfeeding women that could conclude whether this drug can cause harm to an unborn or breastfed child. Therefore, it is best to use this medication only if the potential benefits are greater than the potential risks. 

Frequently Asked Questions 

Is Pradaxa safe? 

Pradaxa is considered safe, although it is a high-alert medicine. Not taking this medication as directed may cause serious harm. 

Is Pradaxa blood thinner? 

Pradaxa is a blood thinner that helps prevent blood clot formation. 

Can I open Pradaxa capsules? 

No. You must swallow this capsule whole because the bioavailability of this drug increases by 75% when taken out of the capsule.  

How should I store Pradaxa? 

Store Pradaxa in a cool, dry place. To protect the capsules from moisture, keep them in the blister package and do not transfer them to a pillbox. 

How much does Pradaxa cost? 

You may see the price of Pradaxa at the top portion of this page. 

Additional information

Scientific Name:

Dabigatran Etexilate, dabigatran etesilate

Formulation:

Capsule

Strength(s):

75mg, 110mg, 150mg

Quantities Available:

60, 90, 100, 120, 180

MedicationsCanada.com receives the above information for Pradaxa (dabigatran etesilate) from third parties. We provide this information for general informational purposes only, and it is not intended to replace the advice of a physician. Any medical concerns should always be discussed with your doctor or a qualified health care professional.