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Motegrity (Prucalopride) Indications

Constipation is a gastric condition in which bowel movements are difficult and occur less frequently than usual.

Individuals with chronic idiopathic constipation (CIC) have a hard time passing stools, and experience infrequent bowel movements, and straining when defecating for at least six months.

A healthy diet and lifestyle changes may help relieve constipation symptoms, but these regimens might not be enough to provide you with the relief you need. Taking Motegrity tablets is one of the pharmaceutical options you can consider.

Motegrity is an oral prescription that enhances the rhythmic movements of the colon muscles, making one have more regular bowel movements. This gastric medication is indicated for adult patients who have chronic idiopathic constipation (CIC).

Motegrity belongs to a class of medications known as serotonin-4 (5-HT4) receptor agonists. Its generic name is prucalopride.

When Motegrity is administered correctly and reaches the bowel, it acts as a gastrointestinal prokinetic agent. Its mechanism of action works by increasing bowel motility.

As a result, Motegrity gastric medication helps relieve gastrointestinal symptoms associated with constipation.

Motegrity (Prucalopride) Uses and Dosage

With Motegrity, people can find relief from the feeling of being bloated, uncomfortable, and sick. It can also help them get through the day and spend the weekend without worrying too much.

The following are the Motegrity’s approved use and dosage:

Treatment of an adult patient with chronic idiopathic constipation (CIC)

When using Motegrity gastric prescription, make sure to read all prescription information and follow all the directions thoroughly. If you are uncertain about how to use prucalopride, talk to your doctor or pharmacist for clarification.

The following are the directions for administering Motegrity (prucalopride):

  • Take one Motegrity tablet once daily or as instructed by your doctor
  • Take Motegrity with or without food.

Side Effects Motegrity (Prucalopride)

Motegrity (prucalopride) tablets may have unwanted side effects that may resolve over time when your body has adjusted to them. Most individuals may experience mild side effects. However, it is best to stop taking this medicine and contact your doctor right away if symptoms become worse or bothersome.

Common Side Effects that may occur when taking Motegrity gastric tablets include: 

  • Headache
  • Nausea
  • Dizziness
  • Gas
  • Stomach pain or bloating
  • Diarrhea
  • Vomiting
  • Fatigue

Serious Side Effects 

  • Unusual changes in mood or behavior
  • Suicidal thoughts or attempts

Allergic Reactions

  • Skin rash
  • Itching
  • Swelling of the face, tongue, throat
  • Trouble breathing or swallowing

Remember that this is not a complete list of all of the potential health risks associated with prucalopride. Contact your healthcare provider for additional information if you experience other side effects not listed above related to Motegrity gastric medication.

Motegrity (Prucalopride) Cautions

Healthcare professionals and patients are warned about the risks of using Motegrity gastric medication, as this medication may lead to suicidal ideation and behavior. Be sure to report immediately to your doctor if you observe sudden changes in mood, behaviors, thoughts, or feelings, such as the following:

  • Worsening of depression
  • Feeling sad
  • Feeling hopeless
  • Having thoughts of hurting oneself
  • Attempts to hurt oneself

Before administering Motegrity gastric medication, make sure to fully disclose your health history to your doctor, especially if you have the following medical conditions, as this will then determine whether this medicine is safe for you:

  • Have kidney problems
  • Have or have had depression, suicidal thoughts or actions, or mood problems
  • Are pregnant or trying to get pregnant
  • Are breastfeeding

Do not take Motegrity if you are allergic to prucalopride or any of its ingredients. Get medical help as soon as possible when allergic reactions develop when using this gastric medication.

Inform your doctor about all the medicines (e.g., vitamins, supplements, etc.) you are taking to prevent unwanted drug interactions with prucalopride.

Do not take Motegrity if you have the following medical problems:

  • A tear in your stomach or intestinal wall (bowel perforation)
  • Bowel blockage (intestinal obstruction)
  • Serious conditions of the intestinal wall (e.g., Crohn’s disease or ulcerative colitis)

Keep prucalopride tablets out of reach of the children and store them safely to preserve their effectiveness.

Motegrity (Prucalopride) Form and Strength

Motegrity gastric medication is available in film-coated tablet formulation with the following strengths:

  • Motegrity
    • 1 mg film-coated tablet
    • 2 mg film-coated tablet

FAQ

What is Motegrity (prucalopride) used for?

Motegrity gastric medication is commonly used to help relieve constipation symptoms in adult patients with chronic idiopathic constipation (CIC).

Is Motegrity (prucalopride) considered a laxative?

Motegrity gastric medication is not a laxative. It is a serotonin-4 (5-HT4) receptor agonist that targets the serotonin receptors in the colon that help boost contraction of the colon and causes stool to pass easier.

Is Motegrity (prucalopride) the same as Linzess?

No, although both medications can be used to help relieve stomach symptoms due to constipation, Motegrity contains prucalopride, while Linzess has an active ingredient known as linaclotide. In addition, Motegrity is a serotonin-4 (5-HT4) receptor agonist, while Linzess is a guanylate cyclase-C (G-CC) agonist.

What type of drug is Motegrity (prucalopride)?

Motegrity belongs to a class of medicines known as serotonin-4 (5-HT4) receptor agonists that will function as a gastrointestinal prokinetic agent to increase bowel motility, thereby relieving constipation.

What are the common side effects of taking Motegrity (prucalopride)?

Common side effects that may occur when taking Motegrity gastric medication include:

  • Headache
  • Nausea
  • Dizziness
  • Gas
  • Stomach pain or bloating
  • Diarrhea
  • Vomiting
  • Fatigue

Additional information

Scientific Name:

Prucalopride Succinate

Formulation:

Film Coated Tablet, Tablet

Strength(s):

1mg, 2mg

Quantities Available:

28, 56, 84, 100

MedicationsCanada.com receives the above information for Motegrity (Prucalopride Succinate) from third parties. We provide this information for general informational purposes only, and it is not intended to replace the advice of a physician. Any medical concerns should always be discussed with your doctor or a qualified health care professional.