Buy Linzess (Linaclotide) Online From Medications Canada.

Linzess (Linaclotide) Indications

Although eating a healthy diet and lifestyle modifications may aid with symptom management associated with constipation, these practices might not be sufficient to bring you the comfort you need. One of the pharmaceutical options you may consider taking is taking Linzess capsules.

Linzess is an oral prescription that enables patients to have a more regular movement and soften stool texture. It is approved for adult patients suffering from irritable bowel syndrome with constipation (IBS‑C) and chronic idiopathic constipation (CIC).

Linzess belongs to a class of medications known as guanylate cyclase-C (G-CC) agonists. Its generic name is linaclotide.

When Linzess is administered correctly and reaches the bowel, it acts locally in the intestine. Its mechanism of action works by binding to G-CC, which can increase cyclic guanosine monophosphate (cGMP).

Increased cGMP stimulates the secretion of chloride and bicarbonate into the intestines by activating the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel, leading to increased intestinal fluid and accelerated bowel movement.

Linzess also helps calm pain-sensing nerves, thereby relieving stomach pain, discomfort, and bloating associated with IBS-C and CIC.

Linzess (Linaclotide) Uses and Dosage

Linzess (linaclotide) is used for the treatment of irritable bowel syndrome with constipation (IBS‑C) and chronic idiopathic constipation (CIC).

With Linzess, people can engage in social events, family reunions, and work-related activities without worrying about belly pain or discomfort brought on by IBS-C and CIC.

The dosage and frequency of linaclotide differ from one person to another. Typically, it will depend on the severity of the client’s existing health problem, age, and tolerance to the regimen. If you are uncertain how to use this gastric medication, talk to your healthcare provider for clarification.

Treatment of irritable IBS‑C

• The recommended dose to treat IBS-C is 290 mcg once a day or as prescribed.

Treatment of CIC

• The suggested dose to treat CIC is 145 mcg once a day or as prescribed. A dose of 72 mcg may also be used based on individual condition and tolerability.

The following are the directions for administering Linzess (linaclotide):

• Take Linzess 30 minutes before the first meal of the day on an empty stomach.
• Make sure to swallow the whole capsule without chewing, crushing, or cutting the pill.
• For patients having a hard time ingesting the medication:
  • Oral administration in applesauce
    1. In a clean container, put one teaspoonful of applesauce.
    2. Open the capsule.
    3. Pour the entire contents into the applesauce.
    4. Consume the whole mixture immediately without chewing.
  • Oral administration in water
    1. In a clean container, pour 30 mL (1 ounce) of water.
    2. Open the capsule.
    3. Pour the entire contents in the water.
    4. Gently mix the beads and the water for at least 20 seconds.
    5. Swallow the water and bead mixture immediately without chewing.
    6. Add another 30 mL, swirl, and swallow right away.
  • Administration via a nasogastric or gastrostomy feeding tube.
    1. Open the capsule and pour the entire contents into a clean container with 30 mL of water.
    2. Swirl beads for at least 20 seconds.
    3. Pull up the water-bead mixture into an appropriately sized catheter-tipped syringe and dispense the syringe contents into the nasogastric tube (at a rate of 10 mL/10 seconds)
    4. Add another 30 mL of water into the nasogastric tube and repeat the process. It is not necessary to flush all the beads to administer the complete dose.
    5. After administering the medicine, flush the feeding tube with 10 mL water.

Side Effects Linzess (Linaclotide)

Linzess (linaclotide) capsules may have unwanted side effects that may resolve over time when your body has adjusted to the regimen. Most individuals may experience mild side effects. However, it is best to contact your doctor right away if it becomes persistent and bothersome.

Common side effects that may occur when taking Linzess capsules include: 

• Diarrhea
• Gas or flatulence
• Stomach pain
• Distended stomach

Serious Side Effects 

• Severe persistent diarrhea

Allergic Reactions

• Skin rash
• Hives
• Skin blisters or peeling
• Swelling (face/tongue/throat)
• Trouble breathing or swallowing

Remember that this is not a complete list of all the potential health risks associated with linaclotide. Consult your healthcare provider for additional information about other side effects not listed above related to Linzess gastric medication.

Linzess (Linaclotide) Cautions

This medication is not recommended in individuals under 18 years old, because it can cause severe dehydration.

Before administering Linzess gastric medication, make sure to fully disclose your health history to your doctor, especially if you are pregnant or are a lactating woman.

Do not take Linzess if you are allergic to linaclotide or any of its other ingredients. Get medical help as soon as possible when hypersensitivity reactions develop when using this gastric medication.

Inform your doctor about all the medicines you are taking to prevent unwanted drug interactions with linaclotide.

Do not take Linzess if you have a bowel blockage (intestinal obstruction), as this can aggravate your current condition.

Keep this gastric medication out of reach of the children and store them safely to preserve their effectiveness.

Linzess (Linaclotide) Form and Strength

This gastric medication is available in capsule formulation with the following strengths:

• Linzess
  • 72 mcg capsule
  • 145 mcg capsule
  • 290 mcg capsule

FAQ

Questions

What exactly does Linzess (linaclotide) do?

Linzess increases intestinal fluid, softens stool texture, and calms pain-sensing nerves, thereby relieving stomach pain, discomfort, and bloating associated with IBS-C and CIC.

How quickly does Linzess (linaclotide) help relieve constipation?

The effect of this medication depends on how your body responds to it. When Linzess is typically taken daily, it can provide constipation relief and other stomach symptoms within one week of taking this medication. The medicine may continue to work more effectively over the next 12 weeks.

Is Linzess (linaclotide) a laxative or stool softener?

No, Linzess medication is not a laxative. It belongs to a class of medicines known as guanylate cyclase-C (G-CC) agonists. It helps manage constipation, calms pain-sensing nerves and accelerates bowel movements to help relieve abdominal symptoms associated with IBS-C and CIC.

What are the common side effects of taking Linzess (linaclotide)?

Common side effects that may occur when taking Linzess include:

• Diarrhea
• Gas or flatulence
• Stomach pain
• Distended stomach