Jentadueto (Linagliptin/Metformin)

What is Jentadueto (Linagliptin/Metformin)?

Jentadueto (Linagliptin/Metformin) includes two oral antihyperglycemic medications used to treat type 2 diabetes: linagliptin and metformin hydrochloride.

• Linagliptin is an orally active dipeptidyl peptidase-4 (DPP-4) inhibitor.
• Metformin Hydrochloride (N, N-dimethylimidodicarbonimidic diamide hydrochloride) is not connected to other classes of oral antihyperglycemic medicines chemically or pharmacologically.

Jentadueto pills include the following strengths: 2.5 mg linagliptin and 1000 mg metformin hydrochloride (Jentadueto 2.5 mg/1000 mg), 2.5 mg linagliptin and 500 mg metformin hydrochloride (Jentadueto 2.5 mg/500 mg), and 2.5 mg linagliptin and 850 mg metformin hydrochloride (Jentadueto 2.5 mg/850 mg).

What is Jentadueto (Linagliptin/Metformin) Used For?

The drugs linagliptin and metformin are found in this combination product. Both drugs are used to keep blood glucose levels under control in persons with type 2 diabetes. Linagliptin belongs to the class of drugs known as DPP-4 inhibitors. It works by boosting the quantity of incretin that the gut produces. When blood sugar levels are high (particularly after a meal), incretin elevates insulin levels. It lowers the amount of sugar produced by the body. Metformin is a member of the class of medicines known as oral hypoglycemics, which control blood sugar levels. Metformin lowers the quantity of glucose the liver produces and makes it simpler for glucose to enter the body’s tissues.

Metformin has been demonstrated to be very effective in postponing diabetes complications in overweight diabetics.

When diet, exercise, weight loss, and other drugs have not been proven to control blood glucose well enough, this combination medication can be used on its own or in conjunction with sulfonylureas such as glyburide or insulin.

Common Side Effects of Jentadueto (Linagliptin/Metformin)

At least 1% of patients taking Jentadueto (Linagliptin/Metformin) have reported the following side effects. Many of these side effects are manageable, and some may go away alone.

Contact your doctor if any of these side effects are severe or bothersome. Your pharmacist can advise you with advice on how to deal with side effects.

• bloating
• cough
• diarrhea
• constipation
• gas
• heartburn
• enhanced sunlight sensitivity
• appetite loss
• tongue flavor of metal
• ulceration of the mouth
• nausea
• clogged nose
• throat pain
• clogged nose

Other than the stated adverse effects, some persons may encounter them. If you experience any concerning symptoms while taking this medicine, consult your doctor.

Warnings and Interactions for Jentadueto (Linagliptin/Metformin)

Before you start taking Jentadueto (Linagliptin/Metformin), tell your doctor about any medical conditions or allergies, any medications you are taking, whether you are pregnant or breastfeeding, and other important health information.

These factors may have an impact on how you take this drug:

• Alcohol consumption

  Alcohol consumption raises the chance of developing lactic acidosis in metformin users. Avoid excessive alcohol consumption if you are taking this medicine. If you drink alcohol frequently or heavily, talk to your doctor about how this drug may affect you, how your alcohol consumption may influence the medication’s dose and effectiveness, and whether any extra monitoring is required.

• Anemia

  Metformin can occasionally induce anemia (low quantities of red blood cells). Contact your doctor when you notice symptoms of low red blood cell count (anemia), such as shortness of breath, unusual tiredness, or pale complexion.

  Your doctor will perform blood tests regularly to check the number of specific types of blood cells in your blood, including red blood cells.

• Blood sugar monitoring

  Check your blood sugar regularly as agreed upon with your doctor or diabetes educator.

• Congestive heart failure and heart disease

  Jentadueto’s (Linagliptin/Metformin) safety and effectiveness in persons with congestive heart failure (CHF) or heart disease have not been demonstrated. As a result, people with CHF or heart disease should avoid taking this drug.

  Describe to your doctor how this drug may influence your medical condition, how it might impact this medication’s dosage and effectiveness, and whether it is appropriate for you if you have CHF or heart disease.

Jentadueto (Linagliptin/Metformin) may interact with any of the following medications:

• acetazolamide
• Acetylsalicylic acid (ASA) (ASA)
• alcohol
• androgens (e.g., testosterone) (e.g., testosterone)
• inhibitors of angiotensin-converting enzymes (ACEIs; e.g., captopril, lisinopril, ramipril)
• apalutamide
• Atypical antipsychotic drugs (e.g., aripiprazole, clozapine, olanzapine, quetiapine, risperidone)
• basiliximab
• bictegravir
• bosentan
• carbamazepine
• cephalexin
• chloroquine
• cimetidine
• corticosteroids inhaled (e.g., budesonide, ciclesonide, fluticasone)

Most Common Questions About Jentadueto (Linagliptin/Metformin)

Is Jentadueto (Linagliptin/Metformin) safe to take while pregnant?

Metformin should not be taken while pregnant. Contact your doctor right away if you become pregnant while taking this medicine. When using insulin, blood glucose levels should be kept as close to normal as feasible during pregnancy.

Is Jentadueto (Linagliptin/Metformin) safe to take while breastfeeding?

It is unknown whether linagliptin enters breast milk. Metformin can be found in breast milk. This medicine may affect your infant if you are breastfeeding. Hence it is not recommended that you use linagliptin-metformin.

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Price of Jentadueto (Linagliptin/Metformin)

The cost of Jentadueto (Linagliptin/Metformin) can vary depending on your needed dosage and quantity. Check out the top of this page for our list of prices.