Buy Entresto (Sacubitril/Valsartan) Online From Medications Canada.

Entresto (Sacubitril /Valsartan) Indications

When the heart is too weak and cannot pump sufficient blood to supply the body, major organs like the lungs or kidneys are deprived of oxygen and the nutrients they need. Hence, these organs cannot work appropriately.

Entresto is an oral prescription indicated for adult patients with chronic heart failure to help reduce the possibility of cardiovascular death and hospitalization. In addition, it helps treat children one-year-old and above who have symptomatic heart failure with systemic left ventricular systolic dysfunction.

The generic name of Entresto is sacubitril/valsartan. It belongs to a class of medications known as neprilysin inhibitors and angiotensin receptor blockers.

Entresto contains two active components that work hand in hand in treating patients with chronic heart failure by helping the heart pump blood throughout the body more easily.

When Entresto medicine is taken correctly and absorbed into the bloodstream, it works by blocking the action of neprilysin through LBQ657, the active form of the prodrug sacubitril. Neprilysin is an enzyme that breaks down peptides, which are small protein pieces that help remove sodium and water from the body.

By inhibiting the action of neprilysin, sacubitril increases the formation of peptides, leading to the removal of sodium and fluid from the body. Less sodium and fluid in the body helps to relieve the strain on the heart.

In addition, valsartan inhibits the angiotensin II type-1 (AT1) receptor. This action relaxes the blood vessels and allows kidneys to get rid of extra water and sodium, thereby decreasing blood pressure levels and making it easier for the heart to pump blood throughout the body.

Entresto (Sacubitril /Valsartan) Uses and Dosage

The dosage and frequency of Entresto is typically personalized depending on the need of the patients. It is usually based on the severity of the client’s existing health problem, comorbidities, age, and response to the medication.

When using Entresto, read all prescription information and follow all the directions thoroughly. If you are not sure about how to use this oral pill, talk to your doctor or pharmacist for clarification.

The following are the uses and recommended dosages of Entresto:

Treatment of adults with heart failure

• The recommended intake to treat adult patients with heart failure is 49/51 mg twice daily. After two to four weeks, the dosage can be doubled to 97/103 mg two times a day, as tolerated.

Treatment of pediatric heart failure

• The suggested dosage to treat pediatric patients one year old and above with heart failure depends on their weight. However, it is usually given twice daily, and the dose is adjusted every two weeks.
• For children less than 40 kg, the starting dose is 1.6 mg/kg. The dose increases to 2.3 mg/kg after two weeks and then 3.1 mg/kg subsequently.
• For a pediatric patient weighing less than 50 kg, the initial dose is 24/26 mg twice daily. With a two-week interval, the dosage can be increased to 49/51 mg twice daily and 72/78 mg twice daily after that.
• For a pediatric patient with at least 50 kg, the starting intake is 49/51 mg twice daily. With a two-week interval, the dose is increased to 72/78 mg twice daily and then 97/103 mg twice daily.

The following are the directions for administering sacubitril/valsartan:

• Administer Entresto orally two times daily or as prescribed by your doctor.
• Consume Entresto whole and avoid chewing, splitting, or crushing the tablets.
• If you have a hard time swallowing the medication whole, ask your healthcare provider about the liquid suspension.

Side Effects of Entresto (Sacubitril /Valsartan)

Entresto may have unwanted side effects similar to other medications that may resolve over time when your body has adjusted to the medicine.

The common side effects that you may experience when taking Entresto are as follows: 

• Low blood pressure
• High potassium levels
  • Muscle weakness
  • Irregular heart rate
• Cough
• Dizziness
• Kidney failure

Serious Side Effects

• Angioedema
  • Swelling of face, lips, tongue, or throat
  • Trouble breathing
• Low blood pressure
• High potassium levels
  • Muscle weakness
  • Irregular heart rate
• Kidney failure

Allergic Reactions

• Skin rash
• Skin itching
• Swelling (face/tongue/throat)
• Trouble breathing

Remember that this is not a complete list of all the potential health problems associated with Entresto. Phone your healthcare provider for additional information if you experience other side effects not listed above.

Entresto (Sacubitril /Valsartan) Cautions

Be vigilant about the risks of using Entresto, especially in pregnant women, as this can cause death to the unborn baby. Do not use this medication if you are pregnant or think you may become pregnant.

Before taking Entresto, fully disclose your medical history to your doctor, especially if you have the following health conditions:

• Have had hereditary angioedema
• Have kidney or liver conditions
• Are pregnant or planning to get pregnant
• Are breastfeeding

Do not take Entresto if you are allergic to sacubitril, valsartan, or any of its other components. Watch out for allergic reactions when using this oral pill.

Do not use Entresto if you have diabetes and are taking medications that contain Aliskiren, as this can worsen your condition. In addition, avoid taking Entresto if you are on ACE inhibitor medication. Make sure to allow a washout period of at least 36 hours when switching from or to an ACE inhibitor medicine.

Make sure to inform your doctor about all the medications you are using to prevent unwanted drug interactions, especially the following:

• Potassium supplements or a salt substitute
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Lithium
• Other medicines like ACE inhibitors, ARBs, or aliskiren

Keep Entresto out of children’s reach and store it in a cool, dry place..

Entresto (Sacubitril /Valsartan) Form And Strength

Entresto is available in tablet formulation with the following strengths:

• Entresto
  • 24/26 mg film-coated tablet
  • 49/51 mg film-coated tablet
  • 97/103 mg film-coated tablet
• Generic Entresto (sacubitril/valsartan)
  • 24/26 mg tablet
  • 49/51 mg tablet
  • 97/103 mg tablet

FAQ

What is Entresto (sacubitril/valsartan) used to treat?

Entresto is indicated for adult patients with chronic heart failure to help reduce the possibility of cardiovascular death and hospitalization.

In addition, it is used to treat pediatric patients one-year-old and above who have symptomatic heart failure with systemic left ventricular systolic dysfunction.

What does Entresto (sacubitril/valsartan) do to the heart?

Entresto treats patients with chronic heart failure by removing excess sodium and water from the body, and helping the heart pump blood throughout the body more easily.

What are the common side effects of Entresto (sacubitril/valsartan)?

Common side effects that you may experience when taking Entresto include: 

• Low blood pressure
• High potassium levels
  • Muscle weakness
  • Irregular heart rate
• Cough
• Dizziness
• Kidney failure